Bostonia. Volume 15

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Effects of low-intensity blood flow restriction training vs. no blood flow restriction training on measures of aerobic capacity in physically active individuals

Background: Blood flow restriction (BFR) training has become an extremely popular training method over the years. Improvements in measures of aerobic capacity (such as VO2max) are crucial for individuals whom seek to be physically active for longer periods of time. Recent studies have focused on the combination of BFR and aerobic exercise at lower training intensities as an adapted training method for either maintaining or improving measures of aerobic capacity in physically active individuals.Clinical Question: In physically active individuals, is low-intensity blood flow restriction training more effective than no blood flow restriction training at improving measures of aerobic capacity?Methods: A computer-assisted literature search of PubMed, MEDLINE, SPORTDiscus, and EBSCOHost databases (from inception to November 2019) was utilized to identify studies of level 3 evidence or higher that assessed the effect of low-intensity BFR training versus no BFR training on measures of aerobic capacity in physically active individuals. The main outcomes of interest were either pre-post testing assessments of aerobic fitness (such as VO2max or VO2peak) and/or pre-post testing assessments of aerobic performance (such as time to exhaustion).Summary of Key Findings: The search strategy revealed 4 studies that met the inclusion criteria. One study reported that there were no significant improvements in measures of aerobic capacity when using low-intensity BFR training versus not using BFR training (1.96%, p < 0.05), while two studies reported that there in fact were significant improvements in measures of aerobic capacity (VO2max: 6.5%, p < 0.05 and TTE: 15.4%, p < 0.01; VO2max: +9.1± 6.2%, P < 0.001). One study reported that there were significant improvements in aerobic capacity when using low-intensity BFR training versus low-intensity training without BFR (BFR group: 5.6 ± 4.2%, P = 0.006, ES = 0.33; LOW group: 0.4 ± 4.7%, P = 0.75); however, high-intensity training without BFR showed greater improvements in aerobic capacity when compared to low-intensity training with BFR (HIT group: 9.2 ± 6.5%, P = 0.002, ES = 0.9).Clinical Bottom Line: There is moderate evidence to support the use of low-intensity BFR training to improve aerobic capacity in physically active individuals.Strength of Recommendation: Grade B evidence exists that low-intensity BFR training is more effective than no BFR training at improving measures of aerobic capacity in physically active individuals

Tsetse fly (Glossina pallidipes) midgut responses to Trypanosoma brucei challenge

Abstract Background Tsetse flies (Glossina spp.) are the prominent vector of African trypanosome parasites (Trypanosoma spp.) in sub-Saharan Africa, and Glossina pallidipes is the most widely distributed species in Kenya. This species displays strong resistance to infection by parasites, which are typically eliminated in the midgut shortly after acquisition from the mammalian host. Although extensive molecular information on immunity for the related species Glossina morsitans morsitans exists, similar information is scarce for G. pallidipes. Methods To determine temporal transcriptional responses of G. pallidipes to Trypanosoma brucei brucei challenge, we conducted Illumina based RNA-seq on midgut organ and carcass from teneral females G. pallidipes at 24 and 48 h post-challenge (hpc) with T. b. brucei relative to their respective controls that received normal blood meals (without the parasite). We used a suite of bioinformatics tools to determine differentially expressed and enriched transcripts between and among tissues, and to identify expanded transcripts in G. pallidipes relative to their orthologs G. m. morsitans. Results Midgut transcripts induced at 24 hpc encoded proteins were associated with lipid remodelling, proteolysis, collagen metabolism, apoptosis, and cell growth. Midgut transcripts induced at 48 hpc encoded proteins linked to embryonic growth and development, serine endopeptidases and proteosomal degradation of the target protein, mRNA translation and neuronal development. Temporal expression of immune responsive transcripts at 48 relative to 24 hpc was pronounced, indicative of a gradual induction of host immune responses the following challenge. We also searched for G. m. morsitans orthologous groups that may have experienced expansions in the G. pallidipes genome. We identified ten expanded groups in G. pallidipes with putative immunity-related functions, which may play a role in the higher refractoriness exhibited by this species. Conclusions There appears to be a lack of strong immune responses elicited by gut epithelia of teneral adults. This in combination with a compromised peritrophic matrix at this stage during the initial phase of T. b. brucei challenge may facilitate the increased parasite infection establishment noted in teneral flies relative to older adults. Although teneral flies are more susceptible than older adults, the majority of tenerals are still able to eliminate parasite infections. Hence, robust responses elicited at a later time point, such as 72 hpc, may clear parasite infections from the majority of flies. The expanded G. m. morsitans orthologous groups in G. pallidipes may also be functionally associated with the enhanced refractoriness to trypanosome infections reported in G. pallidipes relative to G. m. morsitans

Utilizing Low-Intensity Blood Flow Restriction Training to Improve Aerobic Capacity in Physically Active and Injured Individuals: A Critically Appraised Topic

Purpose: To determine if, in physically active individuals, low-intensity Blood Flow Restriction (BFR) training is more effective than training without BFR at improving measures of aerobic capacity. Methods: A database search was conducted for articles that matched inclusion criteria (minimum level 2 evidence, physically active participants, comparison of low-intensity BFR to no BFR training, comparison of pre-post testing with aerobic fitness or performance, training protocols \u3e2 weeks, studies published after 2010) by two authors and assessed by one using the PEDro scale (a minimum of 5/10 was required) to ensure level 2 quality studies that were then analyzed. Results: Four studies met all inclusion criteria. Three of the studies found significant improvements in aerobic capacity (VO2max) using BFR compared to no BFR. While the fourth study reported significant improvements in time to exertion (TTE) training with BFR, this same study did not find significant improvements in measures of aerobic capacity with BFR training. All compared BFR to non-BFR training. It was noted that high-intensity training without BFR was superior to both low-intensity training with and without BFR with respect to improvements in aerobic capacity. Conclusions: Moderate evidence exists to support the use of low-intensity BFR training to improve measures of aerobic capacity in physically active individuals over not using BRF. Clinicians seeking to maintain aerobic capacity in their patients who are unable, for various reasons, to perform high levels of aerobic activity may find low-intensity BFR training useful as a substitution while still receiving improvements in measures of aerobic capacity

Buried refractive microlenses formed by selective oxidation of AlGaAs

Includes bibliographical references (page 1408).The authors demonstrate a novel method of fabricating buried refractive microlenses formed by selective oxidation of AlGaAs epitaxial layers on a GaAs substrate. By appropriate tailoring of the Al mole fraction in the vertical direction, a lens-shaped oxidation shape was achieved. Performance of the microlenses formed in this way was experimentally evaluated at 980nm, and modelled theoretically

Automatic Quantum Error Correction

Criteria are given by which dissipative evolution can transfer populations and coherences between quantum subspaces, without a loss of coherence. This results in a form of quantum error correction that is implemented by the joint evolution of a system and a cold bath. It requires no external intervention and, in principal, no ancilla. An example of a system that protects a qubit against spin-flip errors is proposed. It consists of three spin 1/2 magnetic particles and three modes of a resonator. The qubit is the triple quantum coherence of the spins, and the photons act as ancilla.Comment: 16 pages 12 fig LaTex uses multicol, graphicx expanded version of letter submitted to Phys Rev Let

Flux networks in metabolic graphs

A metabolic model can be represented as bipartite graph comprising linked reaction and metabolite nodes. Here it is shown how a network of conserved fluxes can be assigned to the edges of such a graph by combining the reaction fluxes with a conserved metabolite property such as molecular weight. A similar flux network can be constructed by combining the primal and dual solutions to the linear programming problem that typically arises in constraint-based modelling. Such constructions may help with the visualisation of flux distributions in complex metabolic networks. The analysis also explains the strong correlation observed between metabolite shadow prices (the dual linear programming variables) and conserved metabolite properties. The methods were applied to recent metabolic models for Escherichia coli, Saccharomyces cerevisiae, and Methanosarcina barkeri. Detailed results are reported for E. coli; similar results were found for the other organisms.Comment: 9 pages, 4 figures, RevTeX 4.0, supplementary data available (excel

Counting and computing regions of DD-decomposition: algebro-geometric approach

New methods for $D$-decomposition analysis are presented. They are based on topology of real algebraic varieties and computational real algebraic geometry. The estimate of number of root invariant regions for polynomial parametric families of polynomial and matrices is given. For the case of two parametric family more sharp estimate is proven. Theoretic results are supported by various numerical simulations that show higher precision of presented methods with respect to traditional ones. The presented methods are inherently global and could be applied for studying $D$-decomposition for the space of parameters as a whole instead of some prescribed regions. For symbolic computations the Maple v.14 software and its package RegularChains are used.Comment: 16 pages, 8 figure

COMMUNICATIONS LINK FOR COMPUTERS

A system is disclosed for a computer to communicate with a selected one of a plurality of other computers through two identical communications links associated with the communicating computers. A single channel connects the two links which operate at a clock rate independent of the computers. Binary digits and clock pulses are combined and converted into a three-level signal for serial transmission over the single channel. Both control messages and data words may be transmitted. Each message and word transmitted is checked for error by the receiving link before it is accepted and the receiving computer is interrupted. If error is found, an error message is automatically transmitted to the originating computer

Phase field modeling of electrochemistry II: Kinetics

The kinetic behavior of a phase field model of electrochemistry is explored for advancing (electrodeposition) and receding (electrodissolution) conditions in one dimension. We described the equilibrium behavior of this model in [J. E. Guyer, W. J. Boettinger, J.A. Warren, and G. B. McFadden, ``Phase field modeling of electrochemistry I: Equilibrium'', cond-mat/0308173]. We examine the relationship between the parameters of the phase field method and the more typical parameters of electrochemistry. We demonstrate ohmic conduction in the electrode and ionic conduction in the electrolyte. We find that, despite making simple, linear dynamic postulates, we obtain the nonlinear relationship between current and overpotential predicted by the classical ``Butler-Volmer'' equation and observed in electrochemical experiments. The charge distribution in the interfacial double layer changes with the passage of current and, at sufficiently high currents, we find that the diffusion limited deposition of a more noble cation leads to alloy deposition with less noble species.Comment: v3: To be published in Phys. Rev. E v2: Attempt to work around turnpage bug. Replaced color Fig. 4a with grayscale 13 pages, 7 figures in 10 files, REVTeX 4, SIunits.sty, follows cond-mat/030817